J Alan Diehl Selected Research

Cyclins

1/2022	Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss.
1/2021	The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.
1/2021	Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3.
12/2020	Cyclin D degradation by E3 ligases in cancer progression and treatment.
11/2011	The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation.
1/2011	Breast cancer go sMAD: cyclin towards aggressive phenotypes.
10/2008	SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough.
9/2006	Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.
3/2006	Cyclin D1: polymorphism, aberrant splicing and cancer risk.
12/2005	Location, location, location: the role of cyclin D1 nuclear localization in cancer.

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J Alan Diehl Research Topics

Disease

77	Neoplasms (Cancer) 01/2022 - 05/2002
9	Esophageal Squamous Cell Carcinoma 01/2022 - 09/2008
8	Melanoma (Melanoma, Malignant) 01/2022 - 11/2013
7	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2014
7	Carcinogenesis 09/2019 - 09/2003
5	Genomic Instability 01/2022 - 09/2008
5	Esophageal Neoplasms (Esophageal Cancer) 01/2020 - 11/2003
4	Breast Neoplasms (Breast Cancer) 01/2022 - 05/2002
4	Retinoblastoma (Glioblastoma, Retinal) 01/2021 - 05/2002
4	Squamous Cell Carcinoma of Head and Neck 01/2019 - 01/2016
4	Hypoxia (Hypoxemia) 01/2017 - 11/2008
3	Carcinoma (Carcinomatosis) 01/2022 - 11/2003
3	Inflammation (Inflammations) 01/2022 - 03/2011
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2021 - 11/2017
3	Lymphoma (Lymphomas) 01/2021 - 10/2010
3	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 01/2015
3	Adenocarcinoma 01/2018 - 01/2005
2	Squamous Cell Neoplasms (Squamous Cell Cancer) 01/2022 - 09/2013
2	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2021 - 01/2018
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2020 - 12/2015
2	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 01/2017
2	Necrosis 01/2020 - 03/2016
2	Neuroblastoma 01/2019 - 06/2017
2	Insulin Resistance 06/2012 - 03/2011
2	Virus Diseases (Viral Diseases) 01/2010 - 01/2009
1	Endometrial Hyperplasia 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2019
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2019

Drug/Important Bio-Agent (IBA)

25	Cyclin D1IBA 01/2022 - 05/2002
22	Proteins (Proteins, Gene)FDA Link 02/2021 - 11/2003
16	Phosphotransferases (Kinase)IBA 01/2022 - 04/2002
14	CyclinsIBA 01/2022 - 05/2002
6	Ligases (Synthetase)IBA 12/2020 - 01/2007
5	Protein Kinases (Protein Kinase)IBA 01/2022 - 01/2009
5	UbiquitinIBA 12/2020 - 10/2008
5	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2013 - 11/2006
4	palbociclibIBA 01/2022 - 01/2015
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2020 - 05/2002
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2018 - 01/2018
4	Messenger RNA (mRNA)IBA 11/2017 - 04/2002
3	Pharmaceutical PreparationsIBA 01/2022 - 09/2008
3	Cyclin DIBA 12/2020 - 03/2003
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 11/2007
3	Biological ProductsIBA 06/2017 - 07/2010
3	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 05/2013
3	LipidsIBA 06/2015 - 05/2013
3	Arginine (L-Arginine)FDA Link 03/2015 - 10/2010
3	Crystallins (Crystallin)IBA 10/2008 - 11/2006
2	cholesterol 25-hydroxylaseIBA 01/2021 - 01/2019
2	Inositol (Myoinositol)IBA 09/2019 - 05/2013
2	Amyloid (Amyloid Fibrils)IBA 01/2019 - 01/2015
2	Interferon Type IIBA 01/2019 - 04/2016
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2019 - 05/2013
2	Glutamine (L-Glutamine)FDA Link 01/2019 - 01/2019
2	Cyclin-Dependent Kinase 4IBA 01/2019 - 01/2018
2	Immune Checkpoint InhibitorsIBA 10/2018 - 04/2016
2	RNA (Ribonucleic Acid)IBA 01/2018 - 01/2016
2	Notch ReceptorsIBA 11/2017 - 01/2012
2	PERK kinaseIBA 10/2016 - 01/2015
2	EnzymesIBA 07/2016 - 01/2015
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 07/2016 - 01/2015
2	Activating Transcription Factor 4IBA 07/2015 - 01/2015
2	Oxygen (Dioxygen)IBA 06/2015 - 05/2013
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2014 - 11/2008
2	Insulin (Novolin)FDA Link 06/2012 - 03/2011
2	Peptide Initiation Factors (Initiation Factor)IBA 03/2011 - 04/2002
2	LigandsIBA 01/2010 - 01/2009
2	Protein Isoforms (Isoforms)IBA 09/2006 - 11/2003
1	Tamoxifen FDA LinkGeneric 01/2022
1	CollagenIBA 01/2022
1	Cre recombinaseIBA 01/2022
1	Chimeric Antigen ReceptorsIBA 01/2022
1	Threonine (L-Threonine)FDA Link 01/2022
1	AntigensIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Oxidoreductases (Dehydrogenase)IBA 10/2021
1	Superoxides (Superoxide)IBA 10/2021
1	Ethanol (Ethyl Alcohol)IBA 10/2021
1	SurvivinIBA 01/2021
1	Cyclin D3IBA 01/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2020
1	Conditioned Culture MediaIBA 01/2020
1	Annexin A5IBA 01/2020
1	Propidium (Propidium Iodide)IBA 01/2020
1	SuspensionsIBA 01/2020
1	Caspase 3 (Caspase-3)IBA 01/2020
1	Activating Transcription Factor 6IBA 09/2019
1	Immunoglobulins (Immunoglobulin)IBA 09/2019
1	Reserpine (Serpasil)FDA Link 01/2019
1	Metformin (Glucophage)FDA LinkGeneric 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	InterferonsIBA 01/2019
1	Antihypertensive Agents (Antihypertensives)IBA 01/2019
1	F-Box ProteinsIBA 01/2019
1	OxysterolsIBA 01/2019

Therapy/Procedure

22	Therapeutics 01/2022 - 01/2005
4	Drug Therapy (Chemotherapy) 01/2017 - 03/2009
2	Precision Medicine 01/2020 - 01/2019
1	Transplantation 10/2021
1	Neoadjuvant Therapy 01/2019